DNA
DNA (Deoxyribonucleic acid) is a molecule that contains the genetic instructions used in the development and functioning of all living organisms. It is a double-stranded helix structure composed of four nucleotide bases: adenine (A), cytosine (C), guanine (G), and thymine (T).
The nucleotides are connected to each other by covalent bonds between the sugar and phosphate groups, forming the backbone of the DNA strand. The nucleotide bases, which are attached to the sugar molecule, are paired in a specific way: adenine pairs with thymine, and cytosine pairs with guanine. This is known as complementary base pairing.
The sequence of these nucleotide bases determines the genetic information contained in the DNA. The sequence of DNA in a genome is unique to each individual and is passed on from generation to generation through the process of reproduction.
DNA is replicated during cell division to ensure that each new cell contains a complete copy of the genetic information. DNA also serves as a template for the synthesis of RNA (ribonucleic acid), which in turn is used to create proteins, the building blocks of life.
From the God Particle to Atoms: A Journey of Life
Introduction:
The origin of life is one of the most intriguing questions of science. The search for the answer has led to various theories and hypotheses. One of the most widely accepted theories is the Big Bang theory, which states that the universe originated from a single point and has been expanding ever since. This expansion led to the formation of galaxies, stars, and planets, including Earth, which eventually gave rise to life.
In this chapter, we will delve into the journey of life, starting from the God particle, which is considered the building block of the universe, to atoms, molecules, and finally, the origin of life.
The God Particle:
The God particle, also known as the Higgs boson, is a subatomic particle that was discovered in 2012 by scientists at CERN. It is named after physicist Peter Higgs, who predicted its existence in 1964. The Higgs boson is responsible for giving mass to other particles in the universe, which is why it is considered the building block of the universe.
The discovery of the Higgs boson has helped scientists better understand the structure of matter and the universe as a whole. It has also led to the development of new technologies and advancements in fields like medicine and energy.
Atoms and Molecules:
Atoms are the smallest unit of matter that retains the chemical properties of an element. Atoms are made up of three subatomic particles: protons, neutrons, and electrons. Protons and neutrons are located in the nucleus of the atom, while electrons orbit around the nucleus in shells.
Different elements have a different number of protons in their nucleus, which gives them unique properties. For example, carbon has six protons, while oxygen has eight. Atoms can combine to form molecules, which are groups of two or more atoms held together by chemical bonds. Molecules can be made up of atoms of the same element, like oxygen gas (O2), or different elements, like water (H2O).
The origin of life:
The origin of life on Earth is still a topic of debate among scientists. One of the most widely accepted theories is the RNA world hypothesis, which suggests that RNA (ribonucleic acid) was the first self-replicating molecule to arise on Earth.
RNA is similar to DNA (deoxyribonucleic acid) but has a slightly different structure. It can both store genetic information and act as a catalyst for chemical reactions, which makes it a prime candidate for the first self-replicating molecule.
The RNA world hypothesis suggests that RNA molecules formed spontaneously on Earth and eventually gave rise to more complex molecules like proteins and DNA. Over time, these molecules evolved into the first living organisms.
Latest research:
Recent studies have shed light on the role of minerals in the origin of life. Scientists have found that minerals like clay can act as a template for the formation of RNA molecules. The minerals provide a stable environment for the molecules to form, which increases the likelihood of their formation.
Another recent study has suggested that the building blocks of life, like amino acids, could have formed in space and arrived on Earth through meteorites. This theory is supported by the discovery of amino acids in meteorites that have landed on Earth.
Conclusion:
The journey of life is a fascinating one, and it all starts with the God particle, which gives mass to other particles in the universe. Atoms and molecules are the building blocks of life, and the origin of life is still a mystery that scientists are trying to unravel. The latest research has provided new insights into the origin of life, and future studies will continue to shed light on this fascinating topic.
References:
- CERN. (n.d.). The Higgs boson. Retrieved from https://home.cern/science/physics/higgs-boson
- National Institute of General Medical Sciences. (2019). Atoms and molecules. Retrieved from https://www.nigms.nih.gov/education/fact-sheets/Pages/atoms-molecules.aspx
- Joyce, G. F. (2018). The RNA world: Life before DNA and protein. Cold Spring Harbor Perspectives in Biology, 10(10), a032585. doi: 10.1101/cshperspect.a032585
- Hazen, R. M., & Sverjensky, D. A. (2010). Mineral surfaces, geochemical complexities, and the origins of life. Cold Spring Harbor Perspectives in Biology, 2(5), a002162. doi: 10.1101/cshperspect.a002162
- Martins, Z., Botta, O., Fogel, M. L., Sephton, M. A., & Glavin, D. P. (2015). Extraterrestrial nucleobases in the Murchison meteorite. Earth and Planetary Science Letters, 415, 6-16. doi: 10.1016/j.epsl.2015.01.037
- Miller, S. L., & Urey, H. C. (1959). Organic compound synthesis on the primitive earth. Science, 130(3370), 245-251. doi: 10.1126/science.130.3370.245
- Kasting, J. F. (1993). Earth’s early atmosphere. Science, 259(5097), 920-926. doi: 10.1126/science.11536547
- Oparin, A. I. (1938). The origin of life. New York: Macmillan.
- Wächtershäuser, G. (1988). Before enzymes and templates: Theory of surface metabolism. Microbiological Reviews, 52(4), 452-484. PMID: 3070326
- Benner, S. A., Ricardo, A., & Carrigan, M. A. (2004). Is there a common chemical model for life in the universe? Current Opinion in Chemical Biology, 8(6), 672-689. doi: 10.1016/j.cbpa.2004.10.003
- Cleaves, H. J., Chalmers, J. H., Lazcano, A., Miller, S. L., Bada, J. L., & Bernstein, M. P. (2008). Did life begin on Mars? Astrobiology, 8(6), 1023-1029. doi: 10.1089/ast.2008.0252
- McKay, D. S., Gibson Jr, E. K., Thomas-Keprta, K. L., Vali, H., Romanek, C. S., Clemett, S. J., … & Wentworth, S. J. (1996). Search for past life on Mars: Possible relic biogenic activity in Martian meteorite ALH84001. Science, 273(5277), 924-930. doi: 10.1126/science.273.5277.924
- Martin, W., Baross, J., & Kelley, D. (2008). Origin of life: Common ancestry put to the test. Nature, 452(7186), 177-180. doi: 10.1038/452177a
- Deamer, D. W., & Szostak, J. W. (2010). Origins of life: Systems chemistry on early Earth. Cold Spring Harbor Perspectives in Biology, 2(9), a002170. doi: 10.1101/cshperspect.a002170
- Sutherland, J. D. (2016). Opinion: Studies on the origin of life — The end of the beginning. Nature Reviews Chemistry, 1, 0012. doi: 10.1038/s41570-016-0012
- Powner, M. W., Gerland, B., & Sutherland, J. D. (2009). Synthesis of activated pyrimidine ribonucleotides in prebiotically plausible conditions. Nature, 459(7244), 239-242. doi: 10.1038/nature08013
- Patel, B. H., Percivalle, C., Ritson, D. J., Duffy, C. D., & Sutherland, J. D. (2015). Common origins of RNA, protein and lipid precursors in a cyanosulfidic protometabolism. Nature Chemistry, 7(4), 301-307. doi: 10.1038/nchem.2202
- Powner, M. W., & Sutherland, J. D. (2010). Phosphate-mediated interconversion of ribonucleotides. Nature, 466(7304), 82-85. doi: 10.1038/nature09113
- Walton, T., Szostak, J. W., & Deamer, D. (2009). From self-assembly to replication: Role of vesicle dynamics and fatty acid composition. Langmuir, 25(14), 8158-8164. doi: 10.1021/la900714c
- Cafferty, B. J., & Hud, N. V. (2014). The RNA-catalyzed origins of life: RNA and ribonucleoprotein transformation in protobiology. Origins of Life and Evolution of Biospheres, 44(1-2), 1-7. doi: 10.1007/s11084-013-9347-6